The idea that heartburn is caused by too much stomach acid is still popular in the media and the public. But as Daniel pointed out in the comments section of the last post, anyone familiar with the scientific literature could tell you that heartburn and GERD are not considered to be diseases of excess stomach acid.
Instead, the prevailing scientific theory is that GERD is caused by a dysfunction of the muscular valve (sphincter) that separates the lower end of the esophagus and the stomach. This is known as the lower esophageal valve, or LES. The LES normally opens wide to permit swallowed food and liquids to pass easily into the stomach. Except for belching, this is the only time the LES should open.
Here’s the key point. It doesn’t matter how much acid there is in the stomach. Even a small amount can cause serious damage. Unlike the stomach, the lining of the esophagus has no protection against acid.
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We’ve Been Asking the Wrong Question
a1rax2n Heartburn Relief (👍 Heartburn During Pregnancy) | a1rax2n Tipshow to a1rax2n for In an editorial published in the journal Gastroenterology, the author remarked: (1)
Treating gastroesophageal reflux disease with profound acid inhibition will never be ideal because acid secretion is not the primary underlying defect.
a1rax2n Heartburn Treatments (👍 Heartburn Treatments) | a1rax2n Heartburn Treatmentshow to a1rax2n for I couldn’t agree more. For decades the medical establishment has been directing its attention at how to reduce stomach acid secretion in people suffering from heartburn and GERD, even though it’s well-known that these conditions are not caused by excess stomach acid. Instead, the question researchers should have been asking is, “what is causing the LES to malfunction?” Since it is universally agreed upon that this is the underlying mechanism producing the symptoms of GERD, wouldn’t it make sense to focus our efforts here? That’s exactly what we’re going to do in this article.
GERD Is Caused by Increased Intra-Abdominal Pressure
It is well accepted in the literature that GERD is caused by an increase in intra-abdominal pressure (IAP).
For example, several studies have indicated an association between obesity and GERD, and one paper in Gastroenterology concluded that increased intra-abdominal pressure was the causative mechanism. (2, 3) But while I agree that all of the currently accepted factors play a role, I do not think they are the primary causes of the increased IAP seen in GERD.
The Two Primary Causes of Increased for 1 last update 10 Jul 2020 Intra-Abdominal PressureThe Two Primary Causes of Increased Intra-Abdominal Pressure
In his excellent book, Heartburn Cured, microbiologist Dr. Norm Robillard argues that carbohydrate malabsorption leads to bacterial overgrowth, resulting in IAP which drives reflux. Dr. Robillard makes a strong case that carbohydrate malabsorption plays a significant role in IAP, and I agree. But as I researched this issue I couldn’t help asking: what might be causing the carbohydrate malabsorption in the first place, and are there any other causes of bacterial overgrowth that may precede carbohydrate malabsorption? I believe the one answer to both of those questions is low stomach acid. Low stomach acid can contribute to both bacterial overgrowth (independently of carbohydrate intake) and carbohydrate malabsorption, as I describe below. In a nutshell, the process looks like this: Let’s look at each step in turn.
1. Low Stomach Acid Causes Bacterial Overgrowth
As I explain in the next article, one of the chief roles of stomach acid is to inhibit bacterial overgrowth. At a pH of 3 or less (the normal pH of the stomach), most bacteria can’t survive for more than 15 minutes. But when stomach acid is insufficient and the pH of the stomach rises above 5, bacteria begin to thrive. The gastrin knockout mouse, which is incapable of producing stomach acid, suffers from bacterial overgrowth—as well as inflammation, damage and precancerous polyps in its intestines. (4) It is also well documented that acid-suppressing drugs promote bacterial overgrowth. Long-term use of Prilosec, one of the most potent acid suppressing drugs, reduces the secretion of hydrochloric acid (HCL) in the stomach to near zero. In one trial, 30 people with GERD were treated with a high dose of Prilosec (40g/day) for at least 3 months. (5) Eleven of the 30 Prilosec-treated people had developed significant bacterial overgrowth, compared with only one of the 10 people in the control group.
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Stomach acid (HCL) supports the digestion and absorption of carbohydrates by stimulating the release of pancreatic enzymes into the small intestine. If the pH of the stomach is too high (due to insufficient stomach acid), the pancreatic enzymes will not be secreted and the carbohydrates will not be broken down properly.
Bacterial Overgrowth + Maldigested Carbohydrates = GAS!
a1rax2n To Avoid (👍 Nighttime) | a1rax2n To Avoidhow to a1rax2n for In Hearburn Cured, Dr. Robillard points out that though microbes are able to metabolize proteins and even fats, their preferred energy source is carbohydrate. The fermentation of carbohydrates for 1 last update 10 Jul 2020 that haven’t been digested properly produces gas. The resulting gas increases intra-abdominal pressure, which is the driving force behind acid reflux and GERD. From Dr. Robillard’s book:In Hearburn Cured, Dr. Robillard points out that though microbes are able to metabolize proteins and even fats, their preferred energy source is carbohydrate. The fermentation of carbohydrates that haven’t been digested properly produces gas. The resulting gas increases intra-abdominal pressure, which is the driving force behind acid reflux and GERD. From Dr. Robillard’s book:
According to Suarez and Levitt (17), 30 g of carbohydrate that escapes absorption in a day could produce more than 10,000 mL (ten liters) of hydrogen gas. That is a huge amount of gas!
When stomach acid is sufficient and carbohydrates are consumed in moderation, they are properly broken down into glucose and rapidly absorbed in the small intestine before they can be fermented by microbes. However, if stomach acid is insufficient and/or carbohydrates are consumed in excess, some of the carbs will escape absorption and become available for intestinal microbes to ferment.
Other Supporting Evidence
Dr. Robillard also argues that if gas produced by microbial fermentation of carbohydrates causes acid reflux, we might expect that reflux could be treated by either:
- Reducing bacterial overgrowth, or
- Reducing carbohydrate intake.
He points to two studies which demonstrate this. In a study by Pehl, administration of erythromycin (an antibiotic) significantly decreased esophageal reflux. (6)
In another study by Pennathur, erythromycin strengthened the defective lower esophageal sphincter in patients with acid reflux. (7) To my knowledge, there have only been two small trials performed to test the effects of carbohydrate restriction on GERD. Both had positive results. A small case series showed a significant, almost immediate resolution of GERD symptoms in obese individuals initiating a very-low-carb diet. (8) A more recent study found that a very low-carb diet decreased distal esophagus acid exposure and improved the symptoms of GERD. (9) Perhaps most importantly, the magnitude of the improvement was similar to what has been reported with treatment with proton-pump inhibitors (acid suppressing drugs).
Some researchers now believe that Irritable Bowel Syndrome (IBS) is caused by small intestinal bacterial overgrowth (SIBO). (10) A study performed at the GI Motility Center in Los Angeles in 2002 found that 71 percent of GERD patients tested positive for IBS—double the percentage seen in non-GERD patients being examined. (11) The high prevalence of IBS in GERD patients combined with the recognition that bacterial overgrowth causes IBS is yet another line of evidence suggesting that bacterial overgrowth is also a causative factor in GERD.
To summarize, low stomach acid contributes to bacterial overgrowth in the bowel which in turn can lead to carbohydrate malabsorption (due to decreased pancreatic enzyme secretion). Malabsorption of carbohydrates, as Dr. Robillard has pointed out, increases intra-abdominal pressure and causes GERD.
Where Dr. Robillard and I differ is that I believe low stomach acid is the primary problem with GERD, with carbohydrate malabsorption playing a secondary role. I do think that improper digestion of proteins can, in fact, lead to GERD, whereas Dr. Robillard states in his book that putrefaction of proteins is more likely to cause flatulence. This may be so in most cases, but I’ve seen several patients in my practice on very-low-carbohydrate diets who still experience heartburn, which improves upon restoring proper stomach acid secretion (which we covered in another article in this series). In the Part III of the series I discuss the connection between GERD and H. pylori, and further evidence supporting the theory that GERD is caused by bacterial overgrowth. Read on!
Research Spotlight: Health Coaching and GERD
GERD Patients Demonstrate Difficulty Adhering to Dietary Guidelines
Gastroesophageal reflux disease (GERD), a condition in which stomach contents back up into the esophagus, affects approximately 20 percent of the U.S. population. If left untreated, it can lead to severe complications, including esophagitis, esophageal stricture, respiratory issues, and Barrett’s esophagus. Despite experiencing moderate-to-severe symptoms, many people with GERD continue to consume foods that trigger symptoms. Simply providing these people with a “foods to avoid” list is insufficient for achieving long-term symptom reduction. By providing step-by-step support and guidance, a health coach can help people with GERD better adhere to dietary guidelines and experience lasting improvements in their GERD symptoms.
- GERD is the most common gastrointestinal disease in the United States. The heavy use of acid-suppressing drugs and lost work productivity instigated by GERD contribute a massive financial burden of over $24 billion in the U.S. alone.
- Acid-suppressing drugs are associated with many adverse effects, including an increased risk of fractures, intestinal dysbiosis, and kidney disease. There is a pressing need for nonpharmacologic GERD interventions, such as diet and lifestyle changes.
- Dietary modification is a proposed first-line therapy for GERD. People with GERD are commonly advised to avoid acidic and fried foods, chocolate, alcohol, and large meals. This cross-sectional study sought to examine whether people with GERD follow these guidelines and whether guideline adherence reduces symptoms.
- A validated food frequency questionnaire (FFQ) was administered to each of 308 GERD patients and 182 controls to assess dietary intake of GERD-triggering foods. Each subject also completed a validated GERD symptom survey and medical history.
- Despite reporting moderate to severe symptoms, those with GERD do not adhere to GERD dietary guidelines. They are more likely to consume triggering foods such as soda, liquor, and fried foods, compared to GERD-free controls.
- For dietary modification to be successful at reducing symptoms, people with GERD need support implementing and adhering to these changes.
Multiple studies demonstrate that dietary modification, including the avoidance of processed and fried foods, alleviates GERD symptoms. However, the challenge lies in helping people with GERD stick to these changes over the long term. Health coaching has been found to increase patient adherence to diets and may be key for helping clients make lasting beneficial changes in their diets.
For people with GERD, making dietary changes could be the deciding factor in whether or not they experience symptoms. But eliminating or reducing processed foods, refined carbs, and other staples of the Standard American Diet isn’t an easy change to make. Health coaches support people who are facing those major lifestyle changes. To do this, health coaches tap into their skills—like facilitating change, asking powerful questions, and helping their clients understand their own motivations. Our ADAPT Health Coach Training Program (HCTP) is teaching the next generation of health coaches how to master those skills, support their clients, and fight back against chronic disease. Find out more about the ADAPT HCTP.
The ADAPT Health Coach Training Program is an Approved Health and Wellness Coach Training & Education Program by the National Board for Health and for 1 last update 10 Jul 2020 Wellness Coaching (NBHWC).The ADAPT Health Coach Training Program is an Approved Health and Wellness Coach Training & Education Program by the National Board for Health and Wellness Coaching (NBHWC).
a1rax2n How To Get Rid (🔴 Acid Reflux) | a1rax2n Stops Acid Refluxhow to a1rax2n for I’m in a bit of a quandary. I have been suffering from reflux for years on and off. I’m not overweight but I do eat a fair amount of spicy food, which I’m reluctant to miss out on. I recently tried taking digestive enzymes with betaine hydrochloride, in line with the suggestions here. I have never experienced pain like it! I only took them twice and decided that it definitely wasn’t the answer for me. I’d rather suffer heartburn than that pain.
I suspect that I may have an ulcer. Would that cause reflux, though?
Giving erythromycin to people that already have stomach troubles? Sounds risky. Interesting read though.